Cotranslational protein-RNA associations predict protein-protein interactions
نویسندگان
چکیده
منابع مشابه
Discovering Domains Mediating Protein Interactions
Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
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In order to understand the molecular machinery of the cell, we need to know about the multitude of protein-protein interactions that allow the cell to function. High-throughput technologies provide some data about these interactions, but so far that data is fairly noisy. Therefore, computational techniques for predicting protein-protein interactions could be of significant value. One approach t...
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The problem of how the linear amino acid sequence of a polypeptide folds to assume its unique tertiary structure is one of the most basic and challenging conundrums of contemporary science. Many of the principles and characteristics of protein folding have been learned by studying refolding of denatured polypeptides. However, the problem of protein folding cannot be completely understood withou...
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MOTIVATION A number of methods have been reported that predict protein-protein interactions (PPIs) with high accuracy using only simple sequence-based features such as amino acid 3mer content. This is surprising, given that many protein interactions have high specificity that depends on detailed atomic recognition between physiochemically complementary surfaces. Are the reported high accuracies...
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Knowledge of protein and domain interactions provides crucial insights into their functions within a cell. Various high throughput experimental techniques such as mass spectrometry, yeast two hybrid, and tandem affinity purification have [Q3] generated a significant amount of large-scale high throughput protein interaction data [9,19,21,28,29,35,36,58]. Advances in experimental techniques are p...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2014
ISSN: 1471-2164
DOI: 10.1186/1471-2164-15-298